Endocrine Abstracts

The unresponsiveness of anaplastic thyroid carcinomas (ATCs) to multimodal therapy represents the major challenge in thyroid cancer treatment. Our group previously showed that genes involved in cell cycle are differentially expressed in ATCs compared to normal thyroid, and that the most common mutations found in these tumours are related with proliferation and cell cycle genes, namely TP53, RAS, CDKN2A and CDKN2B. Therefore, these genes are ...

Introduction: Hirsutism is the presence of terminal hair growth in females with a male distribution pattern. It affects 5-15% of women, being an important sign of androgen excess. The main causes of hirsutism are polycystic ovary syndrome (PCOS) and idiopathic hyperandrogenism. Other significant but less frequent causes of hirsutism include nonclassic congenital adrenal hyperplasia (NCAH), androgen-secreting tumors, and Cushing’s syndrome.Case repor...

Introduction: Primary hyperparathyroidism (PHPT) is characterized by parathyroid hormone (PTH) overproduction, causing hypercalcemia. The most common cause is a parathyroid adenoma. PHPT most frequently presents as asymptomatic hypercalcemia or with nonspecific symptoms. Less frequently, it presents with the classical manifestations of bone disease and nephrolithiasis. Acute pancreatitis (AP) as the initial manifestation of PHPT has been reported rarely. Hypercalcemia can caus...

Introduction: Hypocalcemia is a possible complication of thyroid surgery, usually assumed in the context of iatrogenic hypoparathyroidism. On the other hand, Hungry Bone Syndrome (HBS) is a complication classically described after surgical correction of primary hyperparathyroidism. It is characterized by hypocalcemia with normal or elevated PTH values (usually accompanied by hypophosphatemia and hypomagnesemia) and occurs consequently to a compensatory bone formation after a p...

Introduction: POEMS syndrome is a rare multisystem disorder characterized by polyneuropathy, organomegaly, endocrinopathy, monoclonal plasma-proliferative disorder and skin changes. Different endocrinopathies are found in 58-80% of patients, however, its pathophysiology remains unknown. Hypogonadism (primary and secondary) is the most common endocrinopathy (79% of patients), with other abnormalities including hyperprolactinemia (56%), primary hypothyroidism (54%), abnormal glu...

Background: The use of Flash Glucose Monitoring (FGM) for the management of type 1 diabetes mellitus (T1D) is rapidly increasing.Aims: To assess the longitudinal evolution of glycated haemoglobin (HbA1c) and body mass index (BMI) with the use of FGM in patients with T1D; to determine predictive factors of benefit with the use of this technology.Materials and methods: Retrospective study of T1D patients, using FGM ≥6 months an...